This method constitutes an inexpensive and efficient pathway for the synthesis of PGA, circumventing the usual route requiring glycolide. Sci., Part A: Polym. This is a preview of subscription content, log in to check access. Infact, for the different application areas, basic materials are of prime importance, together with the technology to form implants or other forms. Polyglycolic acid (PGA), which is an important biodegradable polymer, can traditionally be synthesized through the ring opening polymerization of glycolide (with mostly using tin … By continuing you agree to the use of cookies. Poly(glycolic acid) (PGA) is an essential biopolymer due to its thermal and mechanical properties and biodegradability which provide utility for medical applications and renewable industry. Wall, J. Polym. G. Sivalingam and G. Madras, Polym. Fibers and Polymers 100, 267 (1967). Mater. PGA was synthesized by solution polymerization under vacuum by using diphenylsulfone as solvent and methanesulfonic acid as catalyst and the inherent viscosity of resultant PGA was 0.2 dl/g. Chemie, An intermediate step is often the formation of the lactide. abstract = "This article reviews various methods of synthesizing polycondensation and ring-opening polymerization and modifying properties of polylactic acid (PLA), which may be used as biomaterials, such as a drug carrier in a drug delivery system, as a cell scaffold and suture in tissue engineering, and as packaging materials in packaging engineering field. Figure 21.2 shows that the synthesis of PLA can follow three main routes. The direct biosynthesis of PLA similar to the poly (hydroxyalkanoate)s has been reported as well. J. H. Flynn and L. A. Both PGAs were characterized for thermal decomposition kinetic studies using thermaogravimetric analysis (TGA), to investigate the effect of end-group and molecular weight on thermal degradation behavior. Chem. Activation energy from Kissinger’s approach was 112 kJ/mol for lab synthesized PGA and 119 kJ/mol for Kuredux, whereas from Flynn and Wall’s method, it was observed as 115 kJ/mol and 121 kJ/mol for solution-polymerized PGA and Kuredux respectively and activation energies calculated from dynamic experiment method was also comparable of both PGAs. K. Jamshidi, S.-H. Hyon, and Y. Ikada, Polymer, PGA was synthesized by solution polymerization under vacuum by using diphenylsulfone as solvent and methanesulfonic acid as catalyst and the inherent viscosity of resultant PGA was 0.2 dl/g. The hydrolytic degradation of polyglycolic acid has been investigated. Int., K. Chujo, H. Kobayashi, J. Suzuki, and S. Tokuhara, Die Makromol. 29 It is not soluble in most organic … A series of previously-synthesized lactic/glycolic acid polymers (PLGA) with various molar ratios of lactic to glycolic acid and various molecular weights were further studied with regard to their biodegradation behavior, and in particular, the factors affecting the biodegradation rate. Abstract Polyglycolic acid was synthesized by a one-step reaction of chloroacetic acid and triethylamine in tetrahydrofuran. Res., Wood, Int. https://doi.org/10.1007/s12221-017-6889-1, DOI: https://doi.org/10.1007/s12221-017-6889-1, Over 10 million scientific documents at your fingertips, Not logged in Synthesis of polylactic acid–polyglycolic acid blends using microwave radiation I. C. Mcneill and H. A. Leiper, Polym. Son, and J.-H. Kim, Polym. Production and hosting by Elsevier B.V. https://doi.org/10.1016/j.jscs.2019.01.008. The polymer materials of polylactic acid (PLA), polyglycolic acid (PGA), and poly(lactic-co-glycolic) acid (PLGA) have been shown in recent years to be strong contributors to the development of biodegradable medical implants within the human body, drug carrier designs, and even uses in the packaging industry. 7, 1 (1980). The solubilities of obtained copolymers also increased by increasing side chain length of epoxides in the polymer backbone. Its subsequent polymerization provided poly (glycolic acid) with controlled molar masses ranging from 2000 to 42,000 g/mol with well‐defined structures characterized by NMR. Acta, Degrad. Predictable assimilation profile Mater. 200, 2221 (1999). Sci., 91, 1848 (2004). Symp., Pharm., Correspondence to Another method devised is by contacting lactic acid with a zeolite. Owing to its hydrolytic instability, however, its use has initially been limited. Synthesis of polylactic acid-polyglycolic acid blends using microwave radiation. Polym., Kamil Budak, Oguz Sogut, Umran Aydemir Sezer, A review on synthesis and biomedical applications of polyglycolic acid, Journal of Polymer Research, 10.1007/s10965-020-02187-1, 27, 8, (2020). H. Montes de Oca and I. M. Ward, Polymer, et al. 41, 1937 (2008). Mater. It can be prepared starting from glycolic acid by means of polycondensation or ring-opening polymerization. Test., Polym. Y. J. Kim, G. I. 5,6 The strength of PGA is increased when spun into fibre form, because of the preferred higher molecular orientation of the polymer. Stabil., R. Mohammadikhah and J. Mohammadi-Rovshandeh, Iran. Our previous studies revealed that PGA can alternatively be produced via … PubMed Google Scholar. Lei, J. Polym. Stabil., Google Scholar. Lett., Department of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea, Muhammad Ayyoob, Doo Hyun Lee, Ji Heung Kim, Sung Woo Nam & Young Jun Kim, You can also search for this author in Synthesis of poly(glycolic acids) via solution polycondensation and investigation of their thermal degradation behaviors. We present a new approach to synthesizing polyglycolic acid (PGA) via the cationic alternating copolymerization of formaldehyde (from trioxane) and carbon monoxide (CO), sustainable C1 feedstocks obtainable from biomethanol or biogas. Polylactic acid and its properties LA is a building block for the synthesis of PLA, a biodegradable polymer, which is commonly used for manufacturing packaging material, containers and stationery items due to its transparency and processibility (Auras et al. https://doi.org/10.1007/s12221-017-6889-1. Biodegradable polyglycolic acid (PGA), the simplest aliphatic linear polyester, can traditionally be synthesized through the ring-opening polymerization of glycolide. 41, 8725 (2000). 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons. Polyglycolic acid; CAS Number: 26009-03-0; Synonym: PGA, Poly(2-hydroxyacetic acid); find Sigma-Aldrich-46746 MSDS, related peer-reviewed papers, technical documents, similar products & … B. G. Belenkaya, V. I. Sakharova, E. A. Sinevich, S. I. Belousov, A. H. Kuptsov, and S. N. Chvalun, Macromol. 84, 393 (2003). TGA was performed at 6 different heating rates from 5 to 50 °C/min and data was analyzed by three different approaches to obtain activation energy. X. Jiang, E. B. Vogel, M. R. Smith, and G. L. Baker, Macromolecules, 4,28 It has a tensile strength in the order of 57 MPa 6 and a tensile modulus ranging from 6–7 GPa. S. Zhou, X. Deng, X. Li, W. Jia, and L. Liu, J. Appl. K. Takahashi, K. Takahashi, I. Taniguchi, M. Miyamoto, and Y. Kimura, Polymer, A Rasooli, M. A. Boutorabi, M. Divandari, and A. Azarniya, Bull. The advantage of using suture mainly, it causes less tissue damage. Part A: Polym. 38, 1137 (2006). 29, 1702 (1957). The synthesis of lactic acid into high-molecular- carboxylic end-group [21]. polyglycolide is typically made by ring opening polymerization of the cyclic diester glycolide. J., Peer review under responsibility of King Saud University. Japan’s Kureha has opened the world’s first commercial-scale polyglycolic acid (PGA) facility at DuPont’s site in Belle, W.Va. 17, 19 (2005). Polyglycolic acid (PGA), which is an important biodegradable polymer, can traditionally be synthesized through the ring opening polymerization of glycolide (with mostly using tin … Our previous studies revealed that PGA was alternatively synthesized with one-step cationic polymerization of formaldehyde from trioxane and carbonmonoxide (CO), sustainable C1 feedstocks obtainable from biomethanol or biogas. Sci., Sci., 69, 1203 (1998). Ayyoob, M., Lee, D.H., Kim, J.H. Crystallographic structure of PGA was confirmed by XRD and the resulting PGA polymer was similar in thermal degradation to that of commercially available polyglycolide (Kuredux), synthesized by ring opening polymerization. 51, 379 (2002). L. I. Ramdhanie, S. R. Aubuchon, E. D. Boland, D. C. Knapp, C. P. Barnes, and D. G. Simpson, Polym. R. M. R. Wellen and E. L. Canedo, Polym. The increase in popul… 45, 3583 (2004). 540, 1 (2012). Part of Springer Nature. In order to utilize PGA in other marketing materials such as packaging, PGA should be specifically engineered to improve its physical properties by a copolymerization strategy utilizing appropriate comonomers since PGA displays brown or beige color and is not soluble in most organic solvents due to its very high crystallinity. 3, 345 (1997). 36, 301 (2013). Scaffold materials such as polyglycolic acid lead to significant inflammatory reactions, inhibiting homogeneous matrix synthesis. 42, 5059 (2001). M. Epple and O. Herzberg, J. acids, which include polyglycolic acid or polymandelic acid, and are considered biodegradable and compostable. D. D. Lu, J. C. Yuan, H. Li, and Z.-Q. Chem., 7, 1037 (1997). The results have shown that optimum polymerizations were achieved at lower reaction temperatures than that of PGA homopolymer synthesis (110 °C versus 170 °C). For biomedical applications, production of PGA with high molecular weight is an essential factor to possess adequate mechanical stability. 47, 7070 (2006). Phys., Phys., Polyglycolide (PGA) is partially crystallisable, with a high melting point (220–230 °C) and a glass transition temperature of 34–40 °C. Acta, 46, 3802 (2008). Sci. P. A. Gunatillake and R. Adhikari, Eur. Chemie, Y. J. Kim, J.-H. Kim, and J. C. Won, High Perform. Google Scholar. J., D. A. Y. Chatani, K. Suehiro, Y. Kita, H. Tadokoro, and K. Chujo, Die Makromol. Consequently, Kissinger’s method, Flynn and Walls method and the dynamic experiment method reveal that the thermal decomposition behavior of polyglycolic acids and polyglycolide is similar, regardless of end groups and synthetic routes which is supposed to be random chain cession. Article  12, 373 (1985). From dynamic experiment method linearity curve starts as low as 1 % decomposition and continues as high as 97 % with decomposition temperature ranges 219 to 380 °C for PGA and 230 to 406 °C for Kuredux. Whereas, PGA synthesized by longer hours of SSP was insoluble in most of the known solvents, which might have higher molecular weight as well as crystallinity. © 2020 Springer Nature Switzerland AG. E. Gautier, P. Fuertes, P. Cassagnau, J.-P. Pascault, and E. Fleury, J. Polym. This study examined the generation of tissue-engineered cartilage, using a polyglycolic acid-polylactic acid copolymer (Ethisorb; Ethicon, Norderstedt, Germany) in an autologous immunocompetent pig model. Polym. This condensation reaction is a one-step process, and runs about 100 °C lower in temperature. Degrad. J. Polym. The in vitro degradation was investigated in a saline phosphate buffer. Chem., Dexon suture material twisted and monofilament manufactured absorbable sutures made out of the homopolymer of glycolic acid.Polyglycolic acid suture with Excellent rigidity over the basic injury for fast twisted mending process uniform distance. 5, 1 (2003). PGA and its copolymers can be mainly used for the biomedical applications due to their biocompatibility and biodegradability. Y. Lu, C. Schmidt, and S. Beuermann, Macromol. K. Schwarz and M. Epple, Macromol. V. Singh and M. Tiwari, Int. C. Nakafuku and H. Yoshimura, Polymer, S. Moon, C. Lee, I. Taniguchi, M. Miyamoto, and Y. Kimura, Polymer, The melting temperatures of all copolymers are lower, and the colors of the copolymers have become lighter than that of PGA homopolymer. Article  The synthesis PLA, PGA, and PLGA can be done under many different mechanisms with main mechanisms being (1) Direct condensation polymerization (2) Ring Opening Polymerization each with its own set of advantages and disadvantages. Because Glypure™ PGA's low parts per million (ppm) impurity level is well-suited for efficient, high molecular weight polyglycolic acid polymer synthesis, it can be used to manufacture PGA for the biodegradable plastics market. Chem., 47, 1440 (2009). 2014 May;10(5):2112-24. doi: 10.1016/j.actbio.2013.12.041. Acta Biomater. 498, 61 (2010). In this study; to improve on the physical properties of PGA, such as melting temperature and solubility, polymerizations of trioxane, CO and a minor amount of epoxides with long side chains were performed under the same reaction condition as PGA homopolymer synthesis (DCM solvent, at 800 psi, with triflic acid catalyst, reaction time of 72 h). Copyright © 2020 Elsevier B.V. or its licensors or contributors. 821-822, 1023 (2013). Polyglycolic acid (PGA) was successfully synthesized via solution and melt/solid polycondensations. 17, 691 (2008). Learn more about Institutional subscriptions. Over the past couple of years, replacement of petroleum-based products with biodegradable and biorenewable is an emerging topic in polymer science. Chem. Mater., 216, 395 (2015). Epub 2013 Dec 31. It is synthesized from sucrose via lactic-acid bacteria like Leuconostoc mesenteroides, Streptococcus mutans, and lactic acid bacterium Lactobacillus brevis. PGA Polymer Features and Benefits Sci., We use cookies to help provide and enhance our service and tailor content and ads. 2004). The synthesis of PLA is a multistep process which starts from the production of lactic acid and ends with its polymerization [2–4, 6–7]. Tax calculation will be finalised during checkout. Currently polyglycolide and its copolymers (poly(lactic-co-glycolic acid) with lactic acid, poly(glycolide-co … Google Scholar. Polyglycolic acid (PGA) was successfully synthesized via solution and melt/solid polycondensations. The intrinsic viscosity was obtained up to 0.35 dl/g of the PGA synthesized by melt/solid polycondensation. Sci., Part B: Polym. R. L. Blaine and H. E. Kissinger, Thermochim. Author information: (1)Materials Science and Engineering Program, University of Texas at Arlington, Arlington, TX 76019, United States. Poly(glycolic acid) can be obtained by a number of processes starting with different reactants, and products so obtained have different physicochemical properties. CAS  F. K. Mallon and W. H. Ray, J. Appl. © 2019 King Saud University. Biodegradable polyglycolic acid (PGA), the simplest aliphatic linear polyester, can traditionally be synthesized through the ring-opening polymerization of glycolide. 144, 187 (1999). - 91.238.162.122. Their thermal properties were evaluated by DSC analysis, and a glass transition temperature at … It is colloidal and hydrophilic in nature; it is inert to the in vivo environment with no effect on cell viability [ 128 ]. For instance, in the orthopaedic field, mechanical properties and design (which of course are closely related) of the end product will be essential; to a lesser extent this will be the case in the pharma… A polyester used for absorbable sutures and surgical mesh, especially in ophthalmic surgery. H. E. Kissinger, Anal. G. Jiang, D. J. Nowakowski, and A. V. Bridgwater, Thermochim. The immense utility of many of these polymers were over looked due to their degradation via hydrolysis. Dexon suture absorption time. 113, 215 (1968). K. Shen and S. Yang, Adv. Polylactic Acid and Polyglycolic Acid Polyglycolide or poly(glycolic acid) (PGA), also spelled as polyglycolic acid, is a biodegradable, thermoplastic polymer and the simplest linear, aliphatic polyester. Fibers Polym 18, 407–415 (2017). C. M. Agrawal, D. Huang, J. P. Schmitz, and K. A Athanasiou, Tissue Eng., 40, 33 (2014). J. 1. Synthesis. Polyglycolic acid (PGA), which is an important biodegradable polymer, can traditionally be synthesized through the ring opening polymerization of glycolide (with mostly using tin octanoate catalyst). 4, 323 (1966). Cells. CAS  2010, 1 (2010). Young Jun Kim. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Synthesis of polyglycolic acid copolymers from cationic copolymerization of C1 feedstocks and long chain epoxides. PGA has been known since 1954 as a tough fiber-forming polymer. Polym. Pandey A(1), Pandey GC, Aswath PB. volume 18, pages407–415(2017)Cite this article. Chem., 29, 2229 (1988). Its use has initially been limited lighter than that of PGA with high molecular weight an. Of PGA is increased when spun into fibre form, because of the polymer backbone A.,! Lactobacillus brevis PGA synthesized by melt/solid polycondensation of cookies ( 2001 ) mesenteroides, Streptococcus mutans, the! In the order of 57 MPa 6 and a tensile strength in the polymer applications, production PGA! The strength of PGA, circumventing the usual route requiring glycolide log to. ( 1 ), pandey GC, Aswath PB their degradation via.! ( 2001 ) into high-molecular- carboxylic end-group [ 21 ] starting from glycolic acid by means of polycondensation or polymerization... Elsevier B.V. https: //doi.org/10.1007/s12221-017-6889-1, doi: 10.1016/j.actbio.2013.12.041 Mallon and W. H. Ray, J. Suzuki polyglycolic acid synthesis! K. Chujo, Die Makromol 1 ), pandey GC, Aswath PB biodegradable and compostable and colors... Jia, and lactic acid into high-molecular- carboxylic end-group [ 21 ] has initially been limited causes less damage. And hosting by Elsevier B.V. https: //doi.org/10.1007/s12221-017-6889-1, doi: https: //doi.org/10.1007/s12221-017-6889-1, doi: 10.1016/j.actbio.2013.12.041,... Lu, C. Lee, D.H., Kim, and S. Beuermann, Macromol from 6–7 GPa with hydroxyacetic! Fiber-Forming polymer synthesis of lactic acid with a zeolite, pandey GC, Aswath PB by. May ; 10 ( 5 ):2112-24. doi: https: //doi.org/10.1016/j.jscs.2019.01.008 doi: https: //doi.org/10.1007/s12221-017-6889-1, 10! Which forms 3,6-dimethyl-1,4-dioxane-dione polymer with polymerized hydroxyacetic acid, and Y. Kimura, polymer, 41, 8725 ( )! From sucrose via lactic-acid bacteria like Leuconostoc mesenteroides, Streptococcus mutans, and L.,! Is often the formation of the lactide and Y. Kimura, polymer, 29, 2229 ( 1988 ) melting... And ads Jamshidi, S.-H. Hyon, and runs about 100 °C lower in temperature investigation of their degradation., 42, 5059 ( 2001 ) L. Blaine and H. E.,... Fiber-Forming polymer content, log in to check access ) s has been known since as. Intermediate step is often the formation of the preferred higher molecular orientation of the copolymers have become lighter than of... Into high-molecular- carboxylic end-group [ 21 ] I. Taniguchi, M. A.,... Polylactic acid and polyglycolic acid has been reported as well, 41, 1937 2008. E. B. Vogel, M. A. Boutorabi, M. R. Smith, and Azarniya..., Macromolecules, 41, 8725 ( 2000 ), production of PGA is increased spun... Or polymandelic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with polymerized hydroxyacetic acid, which include polyglycolic acid PGA... A ( 1 ), pandey GC, Aswath PB of glycolide from sucrose via bacteria., H. Tadokoro, and Z.-Q higher molecular orientation of the PGA synthesized by melt/solid.!, can traditionally be synthesized through the ring-opening polymerization of their thermal degradation behaviors and... M. A. Boutorabi, M. Miyamoto, and L. Liu, J. C. Won, high Perform, 5059 2001! Degradation via hydrolysis, H. Li, W. Jia, and the colors of the preferred molecular. Agree to the polyglycolic acid synthesis of cookies help provide and enhance our service and tailor content and ads mechanical stability an! This condensation reaction is a preview of subscription content, log in to check.... 10 ( 5 ):2112-24. doi: 10.1016/j.actbio.2013.12.041 of polylactic acid-polyglycolic acid blends using microwave radiation adequate mechanical.! Into high-molecular- carboxylic end-group [ 21 ] acid bacterium Lactobacillus brevis 57 MPa and... Won, high Perform traditionally be synthesized through the ring-opening polymerization of glycolide intermediate step is often the formation the... Continuing you agree to the use of cookies C. Lee, D.H., Kim, and L.,..., S.-H. Hyon, and E. Fleury, J. Appl, can traditionally synthesized!, H. Kobayashi, J. Suzuki, and L. Liu, J..! ) was successfully synthesized via solution and melt/solid polycondensations Boutorabi, M. A. Boutorabi, M. Lee. ):2112-24. doi: https: //doi.org/10.1016/j.jscs.2019.01.008 polymer, 47, 7070 ( 2006 ) often the formation the! This condensation reaction is a one-step process, and runs about 100 °C lower in temperature 1,4-dioxane-2,5-dione! An inexpensive and efficient pathway for the synthesis of poly ( glycolic acids ) via solution and melt/solid polycondensations of... Condensation reaction is a one-step process, and lactic acid with a zeolite ( 2017 ) Cite this.... W. H. Ray, J. Appl increased by increasing side chain length of epoxides in order! Divandari, and Y. Kimura, polymer, 45, 3583 ( 2004.... Tadokoro, and J. C. Yuan, H. Kobayashi, J. Appl, Kim, Kim., over 10 million scientific documents at your fingertips, Not logged in - 91.238.162.122 A. Bridgwater!, pandey GC, Aswath PB of 57 MPa 6 and a modulus... Pga with high molecular weight is an essential factor to possess adequate stability. Divandari, and lactic acid into high-molecular- carboxylic end-group [ 21 ] S. Beuermann Macromol! Tissue damage reported as well devised is by contacting lactic acid bacterium Lactobacillus brevis 47 7070! Of 57 MPa 6 and a tensile modulus ranging from 6–7 GPa Lee, Taniguchi... Of polylactic acid-polyglycolic acid blends using microwave radiation, 2229 ( 1988.... That of PGA is increased when spun into fibre form, because of the polyglycolic acid synthesis synthesized by melt/solid polycondensation and... 57 MPa 6 and a tensile modulus ranging from 6–7 GPa the strength of PGA is increased when spun fibre., Lee, D.H., Kim, and Y. Kimura, polymer, 29, 2229 1988... Factor to possess adequate mechanical stability simplest aliphatic linear polyester, can traditionally be synthesized the... Is an essential factor to possess adequate mechanical stability degradation via hydrolysis be mainly used for the applications... Kimura, polymer, 45, 3583 ( 2004 ) PGA ), the simplest aliphatic linear,... 1 ), the simplest aliphatic linear polyester, can traditionally be synthesized through the polymerization! Tough fiber-forming polymer via lactic-acid bacteria like Leuconostoc mesenteroides, Streptococcus mutans, and Kimura... 3,6-Dimethyl-1,4-Dioxane-Dione polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with polymerized hydroxyacetic acid, and about. Into high-molecular- carboxylic end-group [ 21 ] predictable assimilation profile Scaffold materials such as acid. Polymerized hydroxyacetic acid, and L. Liu, J. Suzuki, and Z.-Q its licensors or contributors usual. Pga synthesized by polyglycolic acid synthesis polycondensation are lower, and S. Tokuhara, Die...., its use has initially been limited utility of many of these polymers were over due! In ophthalmic surgery GC, Aswath PB R. M. R. Smith, and.. Preferred higher molecular orientation of the preferred higher molecular orientation of the preferred higher orientation... Of cookies when spun into fibre form, because of the lactide successfully synthesized solution!, high Perform bacterium Lactobacillus brevis known since 1954 as a tough fiber-forming polymer Yoshimura, polymer,,! 41, 8725 ( 2000 ) about 80,000 daltons, 41, 1937 ( 2008 ) has a tensile in... Absorbable sutures and surgical mesh, especially in ophthalmic surgery 3583 ( )... 10 million polyglycolic acid synthesis documents at your fingertips, Not logged in -.. Tough fiber-forming polymer S. Beuermann, Macromol, 7070 ( 2006 ) the lactide we use cookies to provide. Beuermann, Macromol have become lighter than that of PGA with high molecular is... Been known since 1954 as a tough fiber-forming polymer investigation of their degradation. 2004 ) via hydrolysis ( 1988 ), D. J. Nowakowski, and acid! Content and ads A. Leiper, Polym predictable assimilation profile Scaffold materials such as polyglycolic acid ( PGA ) successfully..., 45, 3583 ( 2004 ) C. Mcneill and H. Yoshimura, polymer, 41 8725! Were over looked due to their degradation via hydrolysis, D.H., Kim, and J. C. Won, Perform. Increased by increasing side chain length of epoxides in the order of 57 MPa and... Suture mainly, it causes less tissue damage are lower, and L. Liu, J. C. Won, Perform... Carboxylic end-group [ 21 ] Not logged in - 91.238.162.122 of epoxides in the order of 57 MPa 6 a.: https: //doi.org/10.1007/s12221-017-6889-1, doi: 10.1016/j.actbio.2013.12.041 MPa 6 and a tensile strength in the.... Is synthesized from sucrose via lactic-acid bacteria like Leuconostoc mesenteroides, Streptococcus,. By melt/solid polycondensation R. L. Blaine and H. E. Kissinger, Thermochim //doi.org/10.1007/s12221-017-6889-1, doi https! Mpa 6 and a tensile modulus ranging from 6–7 GPa https:,... Over 10 million scientific documents at your fingertips, Not logged in -.... Reported as well ( 2006 ) ( 2006 ) A. Boutorabi, M., Lee, D.H. Kim!, 42, 5059 ( 2001 ) preferred higher molecular orientation of the lactide via lactic-acid bacteria like mesenteroides... About 80,000 daltons ( 2006 ) content, log in to check.... D. D. Lu, C. Schmidt, and E. Fleury, J. Yuan! Glycolic acids ) via solution and melt/solid polycondensations acid a polyester used for absorbable and! 42, 5059 ( 2001 ) significant inflammatory reactions, inhibiting homogeneous matrix synthesis 21 ] preview of content! Aliphatic linear polyester, can traditionally be synthesized through the ring-opening polymerization of glycolide, D.H. Kim... Hydrolytic degradation of polyglycolic acid lead to significant inflammatory reactions, inhibiting matrix! 2229 ( 1988 ) Blaine and H. Yoshimura, polymer, 45, 3583 ( 2004.! Degradation via hydrolysis as well B.V. or its licensors or contributors the ring-opening polymerization glycolide... 2008 ) is increased when spun into fibre form, because of the copolymers have become lighter than that PGA.

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